The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 09, 2024

Filed:

Apr. 09, 2019
Applicants:

Arizona Board of Regents on Behalf of the University of Arizona, Tucson, AZ (US);

Board of Regents, the University of Texas System, Austin, TX (US);

Inventors:

Scott A. Boitano, Tucson, AZ (US);

Josef Vagner, Tucson, AZ (US);

Theodore J. Price, Austin, TX (US);

Greg Dussor, Austin, TX (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 487/04 (2006.01); C07D 241/36 (2006.01); C07D 487/14 (2006.01); C07D 498/14 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); C07D 487/14 (2013.01); C07D 498/14 (2013.01); A61K 45/06 (2013.01);
Abstract

This invention is in the field of medicinal pharmacology. In particular, the invention relates to a new class of small-molecules having a pyrazino-pyrimidine-dione (or related) structure which function as modulators (activators, inhibitors) of protease activated receptor type 2 (PAR2), and their use as therapeutics for the treatment of conditions involving PAR2 activity (e.g., asthma, chronic pain, cancer and/or vascular disorders).


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