The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 09, 2024
Filed:
Apr. 11, 2019
Applicant:
The University of Melbourne, The University Of Melbourne, AU;
Inventors:
Paul Stephen Donnelly, Melbourne, AU;
Nicholas Alan Zia, Melbourne, AU;
Assignee:
Clarity Pharmaceuticals Ltd, Eveleigh, AU;
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61B 5/00 (2006.01); A61B 8/00 (2006.01); A61B 10/00 (2006.01); A61K 51/04 (2006.01); C07D 487/08 (2006.01);
U.S. Cl.
CPC ...
A61K 51/0482 (2013.01); A61K 51/044 (2013.01); C07D 487/08 (2013.01);
Abstract
The present invention is directed to sarcophagine based compounds of formula (I). The compounds can complex a radioisotope, such as 64-copper and hence are useful in radioimaging and radiotherapy of cancers, e.g. colorectal cancer. The compounds work via a pre-targeting imaging approach in which the tetrazine reacts via click chemistry with a functional group such as a transcyclooctene which is pre-bound to a ligand such as a tumour specific antibody.