The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 09, 2024
Filed:
Feb. 08, 2017
Synaffix B.v., Oss, NL;
Jorge Merijn Mathieu Verkade, Eindhoven, NL;
Maria Antonia Wijdeven, Wijchen, NL;
Petrus Josephus Jacobus Maria Van De Sande, Eindhoven, NL;
Remon Van Geel, Lithoijen, NL;
Floris Louis Van Delft, Nijmegen, NL;
Sander Sebastiaan Van Berkel, Wijchen, NL;
Synaffix B.V., Oss, NL;
Abstract
The present invention is based on the surprising finding that the linker employed in a bioconjugate, such as an anti-body-drug conjugate, is not therapeutically inert but has an effect on the therapeutic index of the bioconjugate. The present invention thus concerns a method for increasing the therapeutic index of a bioconjugate and the bioconjugates for use in treatment, in particular cancer. The bioconjugates according to the invention have a sulfamide linker comprising a group according to formula (1).