The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 09, 2024
Filed:
Aug. 22, 2022
Zhongshi Duqing(shandong) Biotech Co., Ltd, Heze, CN;
Zhao Zhang, Heze, CN;
Jiuxun Zhang, Heze, CN;
Zheng Zhang, Heze, CN;
Jie Li, Heze, CN;
Wei Wei, Heze, CN;
Xiping Zhang, Heze, CN;
Zhongli Pei, Heze, CN;
Shuai Gu, Heze, CN;
Lizhu Niu, Heze, CN;
Zhongshi Duqing(Shandong) Biotech Co., Ltd, Heze, CN;
Abstract
A pea-derived peptide with a muscle-building effect and a preparation method thereof, and a drug and use, are disclosed. A pea protein is subjected to enzymatic hydrolysis, and five polypeptides with muscle-building effect are obtained by separation as separate peptide fragments. In an in vitro aging skeletal muscle cell assay, changes are analyzed in a gene expression level of regulatory pathways related to skeletal muscle cell proliferation and differentiation, apoptosis and autophagy, and protein synthesis and degradation. In addition, animal experiments are conducted to study the muscle-building effect and a corresponding mechanism of the pea-derived peptide. This shows that the five polypeptide sequences have a significant muscle-building effect, usable as a polypeptide drug for the treatment of sarcopenia.