The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 09, 2024
Filed:
Nov. 06, 2020
Applicants:
Memgen, Inc., Houston, TX (US);
H. Lee Moffitt Cancer Center and Research Institute, Inc., Tampa, FL (US);
Inventors:
Mark J. Cantwell, Meadow Vista, CA (US);
Amer A. Beg, Tampa, FL (US);
Assignees:
MEMGEN, INC., Houston, TX (US);
H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC., Tampa, FL (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/761 (2015.01); A61P 35/00 (2006.01); C12N 7/00 (2006.01); C12N 15/113 (2010.01); C12N 15/12 (2006.01); C12N 15/22 (2006.01);
U.S. Cl.
CPC ...
A61K 35/761 (2013.01); A61P 35/00 (2018.01); C12N 7/00 (2013.01); C12N 2710/10021 (2013.01); C12N 2710/10032 (2013.01); C12N 2710/10043 (2013.01); C12N 2710/10071 (2013.01); C12N 2830/00 (2013.01);
Abstract
Disclosed are replication-enhanced oncolytic adenoviruses. These oncolytic adenoviruses have tumor-specific replication capable of enhanced tumor oncolysis and enhanced therapeutic transgene expression. Also disclosed are methods comprising administering a replication-enhanced oncolytic adenovirus for patients suffering from a cancer.