The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 09, 2024
Filed:
Sep. 30, 2020
North Carolina State University, Raleigh, NC (US);
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Jessica M. Gilbertie, Cary, NC (US);
Lauren V. Schnabel, Holly Springs, NC (US);
Thomas P. Schaer, Landenberg, PA (US);
North Carolina State University, Raleigh, NC (US);
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Abstract
An acellular, anion-depleted platelet-derived peptide-rich composition comprising proteins, polypeptides and peptides <10 kDa in size, wherein the composition has anti-microbial and/or anti-inflammatory activity is disclosed. The composition can be substantially free of non-active and immunogenic factors. The composition can have a platelet-to-bacteria ratio ≥1000:1. The composition can comprise plasma at a range of ≥10% to ≤50% plasma, optionally about 10% plasma. Methods of using the composition are also disclosed. Also disclosed is a method for preparing an acellular platelet-derived peptide-rich composition having anti-microbial and/or anti-inflammatory activity, the method comprising: providing a starting material comprising platelet-rich plasma processed to contain ≥1,000,000 platelet/μL, ≤100 leukocytes/μL and ≤10 erythrocyte/μL in plasma; lysing and/or activating the starting material; contacting the starting material with an ion exchange matrix and/or a size exchange matrix; and isolating the acellular platelet-derived peptide-rich composition.