The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 02, 2024
Filed:
Jul. 20, 2020
Applicant:
The University of Chicago, Chicago, IL (US);
Inventors:
Thomas Gajewski, Chicago, IL (US);
Stefani Spranger, Chicago, IL (US);
Assignee:
The University of Chicago, Chicago, IL (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/574 (2006.01); A61K 35/15 (2015.01); A61K 35/17 (2015.01); A61K 39/395 (2006.01); A61K 45/06 (2006.01); C07K 16/28 (2006.01); C12Q 1/6886 (2018.01); G01N 33/50 (2006.01); C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
G01N 33/57496 (2013.01); A61K 35/15 (2013.01); A61K 35/17 (2013.01); A61K 39/395 (2013.01); A61K 39/3955 (2013.01); A61K 39/39558 (2013.01); A61K 45/06 (2013.01); C07K 16/2818 (2013.01); C07K 16/2827 (2013.01); C12Q 1/6886 (2013.01); G01N 33/5017 (2013.01); G01N 33/57484 (2013.01); G01N 33/57492 (2013.01); C12N 15/113 (2013.01); C12N 2310/14 (2013.01); C12Q 2600/158 (2013.01); G01N 2333/4706 (2013.01); G01N 2333/70517 (2013.01);
Abstract
Provided herein are compositions and methods for the treatment of cancer by inhibition of β-catenin or a β-catenin pathway. In particular, inhibitors of β-catenin and/or the Wnt/β-catenin signaling pathway are employed prevent or reverse evasion of immune response or immunotherapy by cancers.