The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 02, 2024
Filed:
Jun. 17, 2022
Applicant:
University of Maryland, Baltimore, Baltimore, MD (US);
Inventors:
Yihua (Bruce) Yu, Ellicott City, MD (US);
Marc Taraban, North Potomac, MD (US);
Assignee:
UNIVERSITY OF MARYLAND, BALTIMORE, Baltimore, MD (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
G01N 24/08 (2006.01); C12N 15/86 (2006.01); G01R 33/44 (2006.01);
U.S. Cl.
CPC ...
G01N 24/08 (2013.01); C12N 15/86 (2013.01); G01R 33/448 (2013.01); C12N 2750/14143 (2013.01);
Abstract
A method of using the relaxation rate (Rand/or R) of solvent NMR signal to noninvasively assess whether viral capsids in a capsid preparation are full or empty, and the percentage of full capsids if the vial contains a mixture of full and empty capsids. The method can simply, rapidly, and non-invasively prove the safety and potency of the capsid preparation and thus whether the capsid preparation can be approved for clinical use, without requiring any sample preparation or reagent addition.