The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 02, 2024
Filed:
Oct. 02, 2019
Applicant:
St. Jude Children's Research Hospital, Inc., Memphis, TN (US);
Inventors:
Steven W. Paugh, Memphis, TN (US);
William E. Evans, Memphis, TN (US);
Erik Bonten, Arlington, TN (US);
Assignee:
St. Jude Children's Research Hospital, Inc., Memphis, TN (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); A61K 31/197 (2006.01); A61K 31/198 (2006.01); A61K 31/401 (2006.01); A61K 31/4025 (2006.01); A61K 31/551 (2006.01); A61K 31/573 (2006.01); A61K 31/713 (2006.01); A61K 38/06 (2006.01); A61K 38/07 (2006.01); A61K 38/57 (2006.01); A61K 45/06 (2006.01); A61P 5/44 (2006.01); C12N 15/113 (2010.01); C12Q 1/6886 (2018.01);
U.S. Cl.
CPC ...
C12N 15/1137 (2013.01); A61K 31/197 (2013.01); A61K 31/198 (2013.01); A61K 31/401 (2013.01); A61K 31/4025 (2013.01); A61K 31/551 (2013.01); A61K 31/573 (2013.01); A61K 31/713 (2013.01); A61K 38/06 (2013.01); A61K 38/07 (2013.01); A61K 38/57 (2013.01); A61K 45/06 (2013.01); A61P 5/44 (2018.01); C12Q 1/6886 (2013.01); C12N 2310/14 (2013.01); C12N 2310/531 (2013.01); C12N 2320/31 (2013.01); C12Q 2600/106 (2013.01); C12Q 2600/154 (2013.01); C12Q 2600/158 (2013.01);
Abstract
The invention provides methods for overcoming glucocorticoid resistance of cancers by inhibition of CASP1. Also disclosed are diagnostic methods for determining glucocorticoid resistance potential by measuring expression level or promoter methylation status of CASP1 gene and/or NLRP3 gene.