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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11945853 B1

PDFFull Text
Date of Patent:
Apr. 02, 2024

Filed:

Jun. 14, 2022

Genetically modified probiotics for oral delivery of renin-angiotensin related therapeutic proteins and peptides

Applicant:

University of Florida Research Foundation, Incorporated, Gainesville, FL (US);

Inventors:

Qiuhong Li, Gainesville, FL (US);

Mohan Raizada, Alachua, FL (US);

Assignee:

UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED, Gainesville, FL (US);

Attorneys:

Timothy H. Van Dyke

WOLTER, VAN DYKE, DAVIS, PLLC

Primary Examiner:

Suzanne M Noakes

Assistant Examiner:

Jae W Lee

Int. Cl.
CPC ...
C07K 14/575 (2006.01); A61K 35/00 (2006.01); A61K 35/74 (2015.01); A61K 35/741 (2015.01); A61K 35/747 (2015.01); A61K 45/06 (2006.01); A61K 48/00 (2006.01); A61P 3/00 (2006.01); A61P 3/10 (2006.01); A61P 9/12 (2006.01); A61P 27/02 (2006.01); A61P 29/00 (2006.01); C07K 7/14 (2006.01); C07K 14/195 (2006.01); C07K 14/28 (2006.01); C07K 14/47 (2006.01); C07K 19/00 (2006.01); C12N 1/00 (2006.01); C12N 9/48 (2006.01);
U.S. Cl.
CPC ...
C07K 14/575 (2013.01); A61K 35/74 (2013.01); A61K 35/741 (2013.01); A61K 35/747 (2013.01); A61K 45/06 (2013.01); A61P 3/00 (2018.01); A61P 3/10 (2018.01); A61P 9/12 (2018.01); A61P 27/02 (2018.01); A61P 29/00 (2018.01); C07K 7/14 (2013.01); C07K 14/195 (2013.01); C07K 14/28 (2013.01); C07K 14/47 (2013.01); C07K 19/00 (2013.01); C12N 1/00 (2013.01); C12N 9/485 (2013.01); A61K 2035/115 (2013.01); A61K 48/00 (2013.01); C07K 2319/02 (2013.01); C07K 2319/50 (2013.01); C07K 2319/60 (2013.01);
Abstract

Provided herein are polynucleic acids and expression vectors for the expression and secretion of angiotensin peptide fragments (e.g., angiotensin-(1-7)) in probiotic bacteria. Provided herein are also probiotic compositions that enable efficient, cost-effective and patient friendly oral therapeutics for treating diverse pathological conditions that involve the renin-angiotensin system (RAS), e.g., pulmonary hypertension, diabetes, diabetic complications, cardiovascular diseases, and ocular inflammatory and neurodegenerative diseases.

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