The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 02, 2024

Filed:

Oct. 04, 2022
Applicant:

Sage Therapeutics, Inc., Cambridge, MA (US);

Inventors:

Gabriel Martinez Botella, Wayland, MA (US);

Boyd L. Harrison, Princeton Junction, NJ (US);

Albert Jean Robichaud, Boston, MA (US);

Francesco G. Salituro, Marlborough, MA (US);

Richard Thomas Beresis, Shanghai, CN;

Assignee:

Sage Therapeutics, Inc., Cambridge, MA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/56 (2006.01); A61K 45/06 (2006.01); C07J 3/00 (2006.01); C07J 9/00 (2006.01); C07J 17/00 (2006.01); C07J 31/00 (2006.01); C07J 33/00 (2006.01); C07J 41/00 (2006.01); C07J 43/00 (2006.01);
U.S. Cl.
CPC ...
C07J 41/0055 (2013.01); A61K 31/56 (2013.01); A61K 45/06 (2013.01); C07J 3/00 (2013.01); C07J 9/00 (2013.01); C07J 17/00 (2013.01); C07J 31/006 (2013.01); C07J 33/002 (2013.01); C07J 43/00 (2013.01); C07J 43/003 (2013.01); C07J 31/00 (2013.01);
Abstract

Described herein are neuroactive steroids of the Formula (II): or a pharmaceutically acceptable salt thereof; wherein A, R, R, R, R, R, R, R, R, Randare as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e.g., such for inducing sedation and/or anesthesia.


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