The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 02, 2024
Filed:
Mar. 15, 2021
Applicant:
Ela Pharma Ltd, Tel Aviv, IL;
Inventors:
Ilana Nathan, Tel Aviv, IL;
Boris Khalfin, Yeroham, IL;
Assignee:
Ela Pharma LTD, Tel Aviv, IL;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 233/04 (2006.01); A61K 31/00 (2006.01); A61K 31/167 (2006.01); A61K 31/4045 (2006.01); A61K 31/415 (2006.01); A61K 31/4178 (2006.01); A61K 31/4196 (2006.01); A61K 31/426 (2006.01); A61K 31/428 (2006.01); A61K 31/4439 (2006.01); A61K 31/454 (2006.01); A61K 31/496 (2006.01); A61K 31/536 (2006.01); A61K 45/06 (2006.01); A61P 25/00 (2006.01); C07C 233/24 (2006.01); C07D 233/44 (2006.01); C07D 233/48 (2006.01); C07D 265/22 (2006.01); C07D 275/06 (2006.01); C07D 277/42 (2006.01); C07D 277/56 (2006.01); C07D 405/06 (2006.01); C07D 417/12 (2006.01); C12N 5/077 (2010.01); C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
C07D 265/22 (2013.01); A61K 31/00 (2013.01); A61K 31/167 (2013.01); A61K 31/4045 (2013.01); A61K 31/415 (2013.01); A61K 31/4178 (2013.01); A61K 31/4196 (2013.01); A61K 31/426 (2013.01); A61K 31/428 (2013.01); A61K 31/4439 (2013.01); A61K 31/454 (2013.01); A61K 31/496 (2013.01); A61K 31/536 (2013.01); A61K 45/06 (2013.01); A61P 25/00 (2018.01); C07C 233/24 (2013.01); C07D 233/44 (2013.01); C07D 233/48 (2013.01); C07D 275/06 (2013.01); C07D 277/42 (2013.01); C07D 277/56 (2013.01); C07D 405/06 (2013.01); C07D 417/12 (2013.01); C12N 5/0669 (2013.01); C12N 15/1137 (2013.01); C12Y 304/14001 (2013.01); C12Y 304/21036 (2013.01); C12N 2310/14 (2013.01); C12N 2501/30 (2013.01); C12N 2501/999 (2013.01);
Abstract
Inhibitor compounds and agents of Cathepsin C, CELA1, CELA3A and/or structurally related molecules thereto, compositions comprising the same, and uses thereof in the inhibition and/or prevention of cell and/or tissue necrosis are described. The compounds include imidazoles of Formula VI: