The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 02, 2024
Filed:
Dec. 29, 2022
Biomea Fusion, Inc., Redwood City, CA (US);
David Sperandio, San Carlos, CA (US);
Xiaodong Wang, Millbrae, CA (US);
Thorsten A. Kirschberg, San Carlos, CA (US);
James T. Palmer, Warrandyte, AU;
Thomas Butler, Redwood City, CA (US);
Solomon B. Ungashe, Sunnyvale, CA (US);
Neil Howard Squires, San Francisco, CA (US);
Nan-Horng Lin, Vernon Hills, IL (US);
Ravindra B. Upasani, San Jose, CA (US);
Amna Trinity-Turjuman Adam, Mountain View, CA (US);
Yongli Su, Foster City, CA (US);
Thu Phan, Fremont, CA (US);
Biomea Fusion, Inc., Redwood City, CA (US);
Abstract
Disclosed herein are heterocyclic compounds, for example, according to the following formula and analogs thereof: that inhibit the activity of FLT3. Also described are specific covalent inhibitors of FLT3. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the FLT3 inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of proliferative diseases or conditions, including hematological malignancies and other diseases or conditions dependent on FLT3 activity.