The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 02, 2024

Filed:

Sep. 17, 2021
Applicants:

Tulavi Therapeutics, Inc., Los Gatos, CA (US);

Incept, Llc, Campbell, CA (US);

Inventors:

Corinne Bright, Mountain View, CA (US);

Yong Ren, Mountain View, CA (US);

Kenneth M. Martin, Mountain View, CA (US);

Farhad Khosravi, Sunnyvale, CA (US);

Amarpreet S. Sawhney, Lexington, MA (US);

Assignees:

Tulavi Therapeutics, Inc., Los Gatos, CA (US);

Incept, LLC, Campbell, CA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61B 17/11 (2006.01); A61B 17/00 (2006.01); A61F 2/00 (2006.01); A61F 2/02 (2006.01); A61K 9/00 (2006.01); A61L 27/18 (2006.01); A61L 27/26 (2006.01); A61L 27/52 (2006.01); A61L 31/14 (2006.01);
U.S. Cl.
CPC ...
A61L 27/26 (2013.01); A61B 17/1128 (2013.01); A61F 2/00 (2013.01); A61F 2/02 (2013.01); A61K 9/0004 (2013.01); A61L 27/18 (2013.01); A61L 27/52 (2013.01); A61L 31/14 (2013.01); A61B 2017/00526 (2013.01); A61F 2210/00 (2013.01); A61F 2210/008 (2013.01); A61F 2240/00 (2013.01); A61F 2240/001 (2013.01); A61F 2250/00 (2013.01); A61L 2400/06 (2013.01); A61L 2430/32 (2013.01);
Abstract

Disclosed are methods, devices and materials for the in situ formation of a nerve cap and/or a nerve wrap to inhibit neuroma formation following planned or traumatic nerve injury. The method includes the steps of identifying a severed end of a nerve, and positioning the severed end into a cavity defined by a form. A transformable media is introduced into the form cavity to surround the severed end. The media is permitted to undergo a transformation from a first, relatively flowable state to a second, relatively non flowable state to form a protective barrier surrounding the severed end. The media may be a hydrogel, and the transformation may produce a synthetic crosslinked hydrogel protective barrier. The media may include at least one anti-regeneration agent to inhibit nerve regrowth.


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