The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 02, 2024
Filed:
Jul. 05, 2022
Applicant:
Alnylam Pharmaceuticals, Inc., Cambridge, MA (US);
Inventors:
Jayaprakash K. Nair, Cambridge, MA (US);
Alexander V Kel'in, Cambridge, MA (US);
Pachamuthu Kandasamy, Cambridge, MA (US);
Kallanthottathil G Rajeev, Cambridge, MA (US);
Muthiah Manoharan, Cambridge, MA (US);
Assignee:
ALNYLAM PHARMACEUTICALS, INC., Cambridge, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 1/00 (2006.01); A61K 31/7088 (2006.01); A61K 47/54 (2017.01); C07C 231/14 (2006.01); C07D 207/12 (2006.01); C07H 15/26 (2006.01); C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
A61K 47/549 (2017.08); A61K 31/7088 (2013.01); C07C 231/14 (2013.01); C07D 207/12 (2013.01); C07H 1/00 (2013.01); C07H 15/26 (2013.01); C12N 15/113 (2013.01); C12N 2310/351 (2013.01); C12N 2320/32 (2013.01);
Abstract
This disclosure relates to an improved process for the preparation of carbohydrate conjugates. The disclosure also relates to carbohydrate conjugated iRNA agents comprising these carbohydrate conjugates, which have improved purity and are advantageous for the in vivo delivery of the iRNA agents.