The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 02, 2024

Filed:

Jun. 20, 2017
Applicants:

The Regents of the University of Michigan, Ann Arbor, MI (US);

Indiana University Research and Technology Corporation, Indianapolis, IN (US);

Inventors:

Scott D. Larsen, South Lyon, MI (US);

Brandt C. Huddle, Ann Arbor, MI (US);

Kun Yang, Ann Arbor, MI (US);

Ronald Buckanovich, Ann Arbor, MI (US);

Thomas Hurley, Indianapolis, IN (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/519 (2006.01); A61K 31/337 (2006.01); A61K 31/4745 (2006.01); A61K 31/522 (2006.01); A61K 31/555 (2006.01); A61K 31/7068 (2006.01); A61K 39/395 (2006.01); A61K 45/06 (2006.01); A61P 31/00 (2006.01); A61P 35/00 (2006.01); C07D 487/04 (2006.01);
U.S. Cl.
CPC ...
A61K 31/519 (2013.01); A61K 31/337 (2013.01); A61K 31/4745 (2013.01); A61K 31/522 (2013.01); A61K 31/555 (2013.01); A61K 31/7068 (2013.01); A61K 39/395 (2013.01); A61K 45/06 (2013.01); A61P 31/00 (2018.01); A61P 35/00 (2018.01); C07D 487/04 (2013.01);
Abstract

This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a thiopyrimidinone structure which function as inhibitors of ALDH protein, and their use as therapeutics for the treatment of cancer and other diseases.


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