The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 02, 2024
Filed:
Feb. 12, 2021
The Children's Medical Center Corporation, Boston, MA (US);
Dana-farber Cancer Institute, Inc., Boston, MA (US);
James Bradner, Weston, MA (US);
Jun Qi, Sharon, MA (US);
Dennis Buckley, Cambridge, MA (US);
Leonard I. Zon, Brookline, MA (US);
Elizabeth Macari, Wilmington, MA (US);
THE CHILDREN'S MEDICAL CENTER CORPORATION, Boston, MA (US);
DANA-FARBER CANCER INSTITUTE, INC., Boston, MA (US);
Abstract
The present invention relates to methods, compositions and kits for treatment of ribosomal disorders and ribosomopathies, e.g. Diamond Blackfan anemia (DBA). In some embodiments, the invention relates to the use of novel classes of compounds, i.e. inhibitors of RSK (p90S6K); inhibitors of p70S6K; and inhibitors of rps6, to treat ribosomal disorders and ribosomopathies. In some embodiments, the invention relates to the use of specific Chk2 inhibitors and to the use of specific phenothiazine derivatives to treat ribosomal disorders and ribosomopathies, e.g. DBA.