The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 26, 2024
Filed:
Jan. 16, 2019
International Business Machines Corporation, Armonk, NY (US);
Seyed Ali Kazemi Oskooei, Zurich, CH;
Maria Rodriguez Martinez, Thalwil, CH;
Matteo Manica, Zurich, CH;
International Business Machines Corporation, Armonk, NY (US);
Abstract
A machine learning model is generated for drug efficacy prediction in treatment of genetic disease from a dataset correlating gene expression data for disease-cell samples with drug efficacy values for the samples. Bias weights are stored that correspond to respective genes in the samples. Each bias weight is dependent on predetermined relevance of the respective gene to drug efficacy. The model is generated by processing the dataset via a tree ensemble method wherein decision trees are grown with splits corresponding to respective genes in the samples. The gene for each split is chosen from a respective subset of the genes, and genes are selected for inclusion in this subset with respective probabilities dependent on the corresponding bias weights. The model is stored, and can be applied to gene expression data measured for a patient to obtain a personalized drug efficacy prediction for devising a personalized course of treatment.