The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 26, 2024

Filed:

Feb. 10, 2022
Applicant:

Zora Biosciences Oy, Espoo, FI;

Inventor:

Reijo Laaksonen, Lempaeaelae, FI;

Assignee:

ZORA BIOSCIENCES OY, Espoo, FI;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/92 (2006.01); A61K 31/164 (2006.01); A61K 31/64 (2006.01); C07B 59/00 (2006.01);
U.S. Cl.
CPC ...
G01N 33/92 (2013.01); A61K 31/164 (2013.01); C07B 59/001 (2013.01); G01N 2405/08 (2013.01); G01N 2458/15 (2013.01); G01N 2800/32 (2013.01); G01N 2800/324 (2013.01); G01N 2800/50 (2013.01); G01N 2800/52 (2013.01);
Abstract

The present invention inter alia provides a method, and use thereof, of predicting CV complications such as AMI, ACS, stroke, and CV death by determining the concentrations of at least one ceramide of Group A and at least one ceramide of Group B in a biological sample and comparing those concentrations to a control. Finding a decreased concentration of at least one Group A ceramide and an increased concentration of at least one Group B ceramide indicates that the subject has an increased risk of developing one or more CV complications. Also provided are a newly identified subset of ceramide molecules, labelled versions thereof, and kits and compositions comprising the same for use in predicting and/or diagnosing CV complications.


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