The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 26, 2024
Filed:
Nov. 04, 2022
Applicant:
Arbor Biotechnologies, Inc., Cambridge, MA (US);
Inventors:
Quinton Norman Wessells, Cambridge, MA (US);
Jeffrey Raymond Haswell, Needham, MA (US);
Tia Marie Ditommaso, Newton, MA (US);
Noah Michael Jakimo, San Francisco, CA (US);
Sejuti Sengupta, Ashland, MA (US);
Assignee:
ARBOR BIOTECHNOLOGIES, INC., Cambridge, MA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 9/22 (2006.01); A61K 31/7105 (2006.01); A61K 38/46 (2006.01); A61K 47/54 (2017.01); A61P 13/12 (2006.01); C12N 9/04 (2006.01); C12N 15/10 (2006.01); C12N 15/11 (2006.01); C12N 15/86 (2006.01); C12N 15/90 (2006.01);
U.S. Cl.
CPC ...
C12N 9/22 (2013.01); A61K 31/7105 (2013.01); A61K 38/465 (2013.01); A61K 47/549 (2017.08); A61P 13/12 (2018.01); C12N 9/0006 (2013.01); C12N 15/102 (2013.01); C12N 15/11 (2013.01); C12N 15/86 (2013.01); C12N 15/907 (2013.01); C12Y 101/01027 (2013.01); C12N 2310/20 (2017.05); C12N 2320/30 (2013.01); C12N 2750/14143 (2013.01); C12N 2800/80 (2013.01);
Abstract
Provided herein are gene editing systems and/or compositions comprising RNA guides targeting LDHA for use in genetic editing of the LDHA gene. Also provide herein are methods of using the gene editing system for introducing edits to the LDHA gene and/or for treatment of primary hyperoxaluria (PH), and processes for characterizing the gene editing system.