The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 26, 2024
Filed:
May. 10, 2019
Fudan University, Shanghai, CN;
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, CN;
Ke Yu, Shanghai, CN;
Jingkang Shen, Shanghai, CN;
Tao Meng, Shanghai, CN;
Jinpeng Pei, Shanghai, CN;
Lanping Ma, Shanghai, CN;
Xin Wang, Shanghai, CN;
Rui Jin, Shanghai, CN;
Zhiyan Du, Shanghai, CN;
Lin Chen, Shanghai, CN;
Ting Yu, Shanghai, CN;
Yongliang Zhang, Shanghai, CN;
Abstract
Disclosed are a new AXL-targeting monoclonal antibody and antibody-drug conjugate. Also disclosed is a method for preparing said antibody and antibody-drug conjugate. The AXL antibody of the present invention can bind with purified human AXL protein and multiple AXL on tumor cell surface with high effectiveness and high specificity. Said humanized antibody also has high affinity and low immunogenicity. Said AXL antibody-drug conjugate has markable performance against tumors having high AXL expression.