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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11938454 B1

PDFFull Text
Date of Patent:
Mar. 26, 2024

Filed:

Dec. 18, 2020

Continuous flow microfluidic system

Applicant:

The University of British Columbia, Vancouver, CA;

Inventors:

Euan Ramsay, Vancouver, CA;

Robert James Taylor, Vancouver, CA;

Timothy Leaver, Delta, CA;

Andre Wild, Vancouver, CA;

Kevin Ou, Toronto, CA;

Colin Walsh, Belmont, CA (US);

Assignee:

The University of British Columbia, Vancouver, CA;

Attorney:

Christensen O'Connor Johnson Kindness PLLC

Primary Examiner:

Lore R Jarrett

Int. Cl.
CPC ...
B01F 25/431 (2022.01); A61K 9/16 (2006.01); B01F 25/432 (2022.01); B01F 25/433 (2022.01); B01F 33/30 (2022.01); B01F 33/81 (2022.01); B01F 101/22 (2022.01); B01J 19/00 (2006.01); G01N 15/00 (2006.01); G01N 35/00 (2006.01);
U.S. Cl.
CPC ...
B01F 25/43161 (2022.01); A61K 9/1682 (2013.01); B01F 25/4323 (2022.01); B01F 25/4331 (2022.01); B01F 33/30 (2022.01); B01F 33/813 (2022.01); B01J 19/0093 (2013.01); B01F 25/43172 (2022.01); B01F 25/431971 (2022.01); B01F 2101/22 (2022.01); B01J 2219/00783 (2013.01); B01J 2219/00822 (2013.01); B01J 2219/00824 (2013.01); B01J 2219/00831 (2013.01); B01J 2219/00833 (2013.01); B01J 2219/00855 (2013.01); B01J 2219/00858 (2013.01); B01J 2219/0086 (2013.01); B01J 2219/00869 (2013.01); B01J 2219/00873 (2013.01); B01J 2219/00889 (2013.01); B01J 2219/00894 (2013.01); B01J 2219/00898 (2013.01); B01J 2219/00986 (2013.01); G01N 2015/0038 (2013.01); G01N 2035/00158 (2013.01);
Abstract

The present disclosure is directed towards improved systems and methods for large-scale production of nanoparticles used for delivery of therapeutic material. The apparatus can be used to manufacture a wide array of nanoparticles containing therapeutic material including, but not limited to, lipid nanoparticles and polymer nanoparticles. In certain embodiments, continuous flow operation and parallelization of microfluidic mixers contribute to increased nanoparticle production volume.

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