The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 26, 2024

Filed:

Mar. 30, 2019
Applicants:

Tlc Biopharmaceuticals, Inc., South San Franciso, CA (US);

Taiwan Liposome Co., Ltd., Taipei, TW;

Inventors:

Keelung Hong, South San Francisco, CA (US);

Yun-Long Tseng, Taipei, TW;

Chun-Yen Lai, Taipei, TW;

Wan-Ni Yu, Taipei, TW;

Hao-Wen Kao, Taipei, TW;

Yi-Yu Lin, Taipei, TW;

Assignees:

Taiwan Liposome Co., Ltd, Taipei, TW;

TLC Biopharmaceuticals, Inc., South San Francisco, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/127 (2006.01); A61K 9/00 (2006.01); A61K 31/445 (2006.01); A61K 47/24 (2006.01); A61K 47/28 (2006.01); A61P 23/02 (2006.01);
U.S. Cl.
CPC ...
A61K 9/1277 (2013.01); A61K 9/0014 (2013.01); A61K 31/445 (2013.01); A61K 47/24 (2013.01); A61K 47/28 (2013.01); A61P 23/02 (2018.01);
Abstract

Provided is an anesthetic composition for locally administering a local anesthetic agent to a subject in need thereof. The anesthetic composition has a lipid based complex prepared by hydrating a lipid cake containing a local anesthetic agent and a lipid mixture with an aqueous buffer solution at a pH higher than 5.5. Also provided is a method to prepare an anesthetic composition using a simpler and more robust for large-scale manufacture and for providing a high molar ratio of local anesthetic agent to phospholipid content as compared to the prior art. This anesthetic composition has a prolonged duration of efficacy adapted to drug delivery.


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