The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 26, 2024

Filed:

Feb. 03, 2017
Applicants:

The Trustees of the University of Pennsylvania, Philadelphia, PA (US);

Sidra Medicine, Doha, QA;

Inventors:

Ravinder Reddy, Gladwyne, PA (US);

Mohammad Haris, Doha, QA;

Hari Hariharan, Mount Laurel, NJ (US);

Puneet Bagga, Philadelphia, PA (US);

Francesco M. Marincola, Palo Alto, CA (US);

Mitchell D. Schnall, Wayne, PA (US);

Assignees:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 49/06 (2006.01); A61B 5/055 (2006.01); A61K 49/10 (2006.01); A61K 51/04 (2006.01); G01R 33/56 (2006.01); A61B 6/03 (2006.01);
U.S. Cl.
CPC ...
A61K 49/06 (2013.01); A61B 5/055 (2013.01); A61K 49/108 (2013.01); A61K 51/0421 (2013.01); A61K 51/0491 (2013.01); G01R 33/5601 (2013.01); A61B 6/037 (2013.01);
Abstract

The present disclosure relates to magnetic resonance imaging (MRI) methods comprising (i) obtaining a baseline chemical exchange saturation transfer (CEST) MRI image of a patient, (ii) administering an effective amount of a non-nutritive sweetener to the patient, and (iii) obtaining one or more test CEST MRI image of the patient subsequent to the administering step (ii); wherein the step (i) and (iii) acquisition parameters are substantially the same. The non-nutritive sweetener may include a natural or artificial sugar alcohol, polyol, or combinations or derivatives thereof.


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