The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 26, 2024
Filed:
May. 01, 2020
Genevant Sciences Gmbh, Basel, CH;
Sean D. Monahan, Lake Forest Park, WA (US);
Michael S. Declue, Seattle, WA (US);
Pierrot Harvie, Seattle, WA (US);
Russell N. Johnson, Seattle, WA (US);
Amber E. Paschal, Redmond, WA (US);
Mary G. Prieve, Lake Forest Park, WA (US);
Debashish Roy, Seattle, WA (US);
Charbel Diab, Tustin, CA (US);
Michael E. Houston, Jr., Kirkland, WA (US);
Anna Galperin, Seattle, WA (US);
Maher Qabar, Sammamish, WA (US);
GENEVANT SCIENCES GMBH, Basel, CH;
Abstract
Described herein are block copolymers, and methods of making and utilizing such copolymers. The described block copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the block copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the block copolymer is endosomolytic and capable of delivering an oligonucleotide (e.g., an mRNA) to a cell. Compositions comprising a block copolymer and an oligonucleotide (e.g., an mRNA) are also disclosed.