The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 26, 2024

Filed:

May. 12, 2023
Applicant:

Astellas Pharma Inc., Tokyo, JP;

Inventors:

Masakazu Miyazaki, Tokyo, JP;

Ryohei Ishiba, Tokyo, JP;

Yuki Takaishi, Tokyo, JP;

Fumiaki Uejo, Tokyo, JP;

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/497 (2006.01); A61K 9/20 (2006.01); A61K 47/10 (2017.01); A61K 47/26 (2006.01);
U.S. Cl.
CPC ...
A61K 31/497 (2013.01); A61K 9/20 (2013.01); A61K 9/2095 (2013.01); A61K 47/10 (2013.01); A61K 47/26 (2013.01);
Abstract

Provided is a stable pharmaceutical composition for oral administration comprising 6-ethyl-3-({3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}amino)-5-(tetrahydro-2H-pyran-4-ylamino)pyrazine-2-carboxamide (hereinafter referred to as compound A) or a pharmaceutically acceptable salt thereof, wherein the generation of related substances during storage is inhibited. In the stable pharmaceutical composition for oral administration, the proportion of crystals of compound A or a pharmaceutically acceptable salt thereof is 60% or more with respect to the total amount of compound A or a pharmaceutically acceptable salt thereof.


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