The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 19, 2024
Filed:
Jun. 18, 2018
Applicant:
University of North Carolina AT Chapel Hill, Chapel Hill, NC (US);
Inventors:
Eliane Wauthier, Chapel Hill, NC (US);
Tsunekazu Oikawa, Chapel Hill, NC (US);
Timothy Anh-Hieu Dinh, Chapel Hill, NC (US);
Praveen Sethupathy, Chapel Hill, NC (US);
Lola M. Reid, Chapel Hill, NC (US);
Assignee:
University of North Carolina at Chapel Hill, Chapel Hill, NC (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/09 (2010.01); C12Q 1/6886 (2018.01); G01N 33/50 (2006.01); G01N 33/574 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0693 (2013.01); A01K 67/0271 (2013.01); C12Q 1/6886 (2013.01); G01N 33/5067 (2013.01); G01N 33/57438 (2013.01); A01K 2207/12 (2013.01); A01K 2227/105 (2013.01); C12N 2503/02 (2013.01); C12N 2513/00 (2013.01); C12Q 2600/158 (2013.01); C12Y 305/01098 (2013.01);
Abstract
The present disclosure provides a model of human fibrolamellar hepatocellular carcinoma (FL-HCC) cells maintained as a transplantable tumor line in a host and a method to establish a transplantable human FL-HCC tumor line. Methods of ex vivo cultures of the FL-HCC are provided. Methods of diagnosing and treating FL-HCC tumors are also provided.