The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 19, 2024
Filed:
Sep. 07, 2018
Applicant:
Jcr Pharmaceuticals Co., Ltd., Ashiya, JP;
Inventors:
Assignee:
JCR Pharmaceuticals Co., Ltd., Ashiya, JP;
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); A61K 9/08 (2006.01); C07K 16/28 (2006.01); C12N 9/16 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2881 (2013.01); A61K 9/08 (2013.01); C12N 9/16 (2013.01); A61K 2039/505 (2013.01); C12Y 301/06013 (2013.01);
Abstract
Aqueous pharmaceutical compositions containing a fusion protein of an antibody and a lysosomal enzyme as an active ingredient, which are stable enough to be marketed, are disclosed. The aqueous pharmaceutical composition, for example, comprises the fusion protein of the antibody and the lysosomal enzyme at a concentration of 0.5 to 20 mg/mL, sodium chloride at a concentration of 0.3 to 1.2 mg/mL, sucrose at a concentration of 50 to 100 mg/mL, a nonionic surfactant at a concentration of 0.15 to 3 mg/mL, a buffer at a concentration of 3 to 30 mM, and is adjusted to pH 5.0 to 7.5.