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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11932698 B1

PDFFull Text
Date of Patent:
Mar. 19, 2024

Filed:

Aug. 29, 2019

Anti-mesothelin chimeric antigen receptor (car) constructs and uses thereof

Applicant:

Nanjing Legend Biotech Co. Ltd., Jiangsu, CN;

Inventors:

Qing Dai, Nanjing, CN;

Jian Liu, Nanjing, CN;

Shuai Yang, Nanjing, CN;

Kun Jiang, Nanjing, CN;

Yuanyuan Peng, Nanjing, CN;

Chen Hu, Nanjing, CN;

Shu Wu, Nanjing, CN;

Assignee:

Nanjing Legend Biotech Co., Ltd., Nanjing, CN;

Attorney:

Fish & Richardson P.C.

Primary Examiner:

Adam Weidner

Assistant Examiner:

Ashley H Gao

Int. Cl.
CPC ...
C07K 16/28 (2006.01); A61K 35/17 (2015.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01); A61P 35/00 (2006.01); C07K 14/705 (2006.01); C07K 14/71 (2006.01); C07K 14/725 (2006.01); C07K 16/30 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2869 (2013.01); A61K 35/17 (2013.01); A61P 35/00 (2018.01); C07K 14/7051 (2013.01); C07K 14/70517 (2013.01); C07K 14/70521 (2013.01); C07K 14/70578 (2013.01); C07K 14/71 (2013.01); C07K 16/3076 (2013.01); A61K 38/00 (2013.01); A61K 2039/505 (2013.01); A61K 2039/5156 (2013.01); A61K 2039/5158 (2013.01); C07K 2317/24 (2013.01); C07K 2317/565 (2013.01); C07K 2317/569 (2013.01); C07K 2317/622 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01); C07K 2319/02 (2013.01); C07K 2319/03 (2013.01); C07K 2319/30 (2013.01); C07K 2319/33 (2013.01);
Abstract

Described herein are T cells engineered to express a chimeric antigen receptor (CAR), such as an anti-mesothelin CAR alone or in combination with a follicle-stimulating hormone receptor (FSHR) binding domain and/or a dominant negative transforming growth factor-β receptor II (dnTGFβRII) for the treatment of diseases associated with mesothelin expression. Also described are T cells engineered to express a modified T cell receptor (TCR).

Find Patent Forward Citations

Dai, Qing. (2024). Anti-mesothelin chimeric antigen receptor (car) constructs and uses thereof (U.S. Patent No. 11932698). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11932698

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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