The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 19, 2024
Filed:
May. 11, 2023
Biontech SE, Mainz, DE;
Genmab A/s, Copenhagen V, DK;
Ugur Sahin, Mainz, DE;
Sina Fellermeier-Kopf, Mainz, DE;
Friederike Gieseke, Mainz, DE;
Karsten Beckmann, Mainz, DE;
Claudia Paulmann, Mainz, DE;
Alexander Muik, Mainz, DE;
Ivan Kuzmanov, Mainz, DE;
Esther Cornelia Wilhelmina Breij, Utrecht, NL;
Patricia Garrido Castro, Utrecht, NL;
Jordan Blum, Utrecht, NL;
Lars Guelen, Utrecht, NL;
Joost Neijssen, Utrecht, NL;
Bart-Jan De Kreuk, Utrecht, NL;
Richard Hibbert, Utrecht, NL;
Janine Schuurman, Utrecht, NL;
Aran Frank Labrijn, Utrecht, NL;
BioNTech SE, Mainz, DE;
Genmab A/S, Copenhagen, DK;
Abstract
The present disclosure relates to antibodies having the ability to bind to the immune checkpoint protein programmed death-1 (PD-1), such as human PD-1, or nucleic acids encoding such antibodies, wherein the antibodies comprise modifications in the Fc region eliminating or reducing a Fc-mediated effector function of the antibodies. The present disclosure also relates to compositions or kits comprising said antibodies or nucleic acids, as well as to the use of these antibodies or nucleic acids or compositions in the field of medicine, preferably in the field of immunotherapy, e.g., for the treatment of cancers. The present invention further relates to methods for inducing an immune response in a subject comprising providing to the subject an antibody of the present disclosure or one or more nucleic acids encoding such an antibody, or a composition comprising said antibody or nucleic acids.