The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 19, 2024
Filed:
Nov. 21, 2019
Applicant:
University of Pittsburgh—of the Commonwealth System of Higher Education, Pittsburgh, PA (US);
Inventors:
Assignee:
UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, Pittsburgh, PA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/68 (2017.01); A61B 5/0515 (2021.01); A61B 5/055 (2006.01); A61K 47/69 (2017.01); A61P 35/00 (2006.01); C07K 16/28 (2006.01); C07K 16/32 (2006.01);
U.S. Cl.
CPC ...
A61K 47/6815 (2017.08); A61B 5/0515 (2013.01); A61B 5/055 (2013.01); A61K 47/6811 (2017.08); A61K 47/6851 (2017.08); A61K 47/6923 (2017.08); A61P 35/00 (2018.01); C07K 16/2827 (2013.01); C07K 16/2842 (2013.01); C07K 16/2863 (2013.01); C07K 16/2866 (2013.01); C07K 16/32 (2013.01);
Abstract
Bioconjugates and methods of making bioconjugates are provided, wherein the bioconjugates comprise glucose oxidase and nanoparticles that can kill tumor cells. For example, glucose oxidase-iron oxide bioconjugates can produce reactive oxygen species from blood glucose, causing cell death. The use of superparamagnetic iron oxide nanoparticles can provide magnetic resonance imaging guidance to facilitate imaging-guided drug delivery and combine diagnostics with therapy.