The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 12, 2024
Filed:
Aug. 02, 2017
Applicant:
Georgetown University, Washington, DC (US);
Inventor:
Anton Wellstein, Washington, DC (US);
Assignee:
Georgetown University, Washington, DC (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/574 (2006.01); C12Q 1/68 (2018.01); C12Q 1/6886 (2018.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
G01N 33/57492 (2013.01); C12Q 1/68 (2013.01); C12Q 1/6886 (2013.01); G01N 33/57484 (2013.01); G01N 33/6848 (2013.01);
Abstract
The present invention provides methods of identifying neopeptides in abnormal cells, with the methods comprising sequencing long-read messenger RNA (mRNA) isolated from the abnormal cells, identifying splice variants that could be generated from the sequenced long-read mRNA, determining if the abnormal cells contain neopeptides that correlate with the identified splice variants. The methods may also comprise identifying at least one neoantigen on the neopeptides that are present in the abnormal cells.