The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 12, 2024
Filed:
Aug. 02, 2019
Applicant:
Dana-farber Cancer Institute, Inc., Boston, MA (US);
Inventors:
Peter Hammerman, Newton, MA (US);
Matthew Meyerson, Concord, MA (US);
Chandra Pedamallu, Belmont, MA (US);
Sam Freeman, Brookline, MA (US);
Assignee:
Dana-Farber Cancer Institute, Inc., Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/6886 (2018.01); G01N 33/574 (2006.01); C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
C12Q 1/6886 (2013.01); G01N 33/57407 (2013.01); G01N 33/57423 (2013.01); G01N 33/57492 (2013.01); C12N 15/1138 (2013.01); C12N 2310/11 (2013.01); C12N 2320/30 (2013.01); C12Q 2600/106 (2013.01); C12Q 2600/112 (2013.01); C12Q 2600/118 (2013.01); C12Q 2600/156 (2013.01); C12Q 2600/158 (2013.01); G01N 2333/4703 (2013.01); G01N 2333/70503 (2013.01); G01N 2333/70596 (2013.01); G01N 2500/00 (2013.01); G01N 2500/04 (2013.01); G01N 2500/10 (2013.01); G01N 2800/50 (2013.01); G01N 2800/52 (2013.01);
Abstract
The present invention relates to methods for identifying, assessing, preventing, and treating cancer (e.g., head, neck, and/or lung cancers in humans). A variety of PD-L1 isoform biomarkers are provided, wherein alterations in the copy number of one or more of the biomarkers and/or alterations in the amount, structure, and/or activity of one or more of the biomarkers is associated with cancer status and indicates amenability to treatment or prevention by modulating PD-1 and/or PD-L1 levels.