The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 12, 2024

Filed:

Aug. 24, 2021
Applicant:

Washington University, St. Louis, MO (US);

Inventors:

David Holtzman, St. Louis, MO (US);

Hong Jiang, St. Louis, MO (US);

Thu Nga Bien-Ly, South San Francisco, CA (US);

Mark S. Dennis, South San Francisco, CA (US);

Jing Guo, South San Francisco, CA (US);

Adam P. Silverman, South San Francisco, CA (US);

Ryan J. Watts, South San Francisco, CA (US);

Yin Zhang, South San Francisco, CA (US);

Assignee:

Washington University, St. Louis, MO (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); A61K 9/00 (2006.01); A61K 9/127 (2006.01); A61K 31/192 (2006.01); A61K 39/00 (2006.01); A61P 25/28 (2006.01); C07K 16/18 (2006.01);
U.S. Cl.
CPC ...
C07K 16/18 (2013.01); A61K 9/0019 (2013.01); A61K 9/0085 (2013.01); A61K 9/127 (2013.01); A61K 31/192 (2013.01); A61P 25/28 (2018.01); A61K 2039/505 (2013.01); C07K 2317/33 (2013.01); C07K 2317/90 (2013.01); C07K 2317/92 (2013.01);
Abstract

The present disclosure encompasses compositions and methods for effectively treating at least one symptom or sign of Aß plaque or cerebral amyloid angiopathy (CAA) associated symptoms, or for decreasing amyloid plaque load or CAA load. The method comprises administering an effective amount of an anti-ApoE antibody to a mammalian subject, such as to a human.


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