The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 12, 2024
Filed:
Mar. 19, 2021
The Johns Hopkins University, Baltimore, MD (US);
Ústav Organické Chemie a Biochemie Av {hacek Over (C)}r, V.v.i., Prague, CZ;
Barbara Slusher, Kingsville, MD (US);
Rana Rais, West Friendship, MD (US);
Lukas Tenora, Prague, CZ;
Pavel Majer, Sykesville, MD (US);
Andrej Jancarik, Koprivnice, CZ;
The Johns Hopkins University, Baltimore, MD (US);
Ústav organické chemie a biochemie AV {hacek over (C)}R, v.v.i., Prague, CZ;
Abstract
The disclosure provides compounds having formula (I): and the pharmaceutically acceptable salts thereof, wherein R, R, R′, and X are as defined as set forth in the specification. Compounds having formula (I) are prodrugs that release glutamine analogs, e.g., 6-diazo-5-oxo-L-norleucine (DON). The disclosure also provides compounds having formula (I) for use in treating cancer.