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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11926632 B1

PDFFull Text
Date of Patent:
Mar. 12, 2024

Filed:

Jun. 21, 2021

Methods and compounds for restoring mutant p53 function

Applicant:

Pmv Pharmaceuticals, Inc., Cranbury, NJ (US);

Inventors:

Binh Vu, North Caldwell, NJ (US);

Romyr Dominique, East Brunswick, NJ (US);

Hongju Li, Edison, NJ (US);

Bruce Fahr, East Windsor, NJ (US);

Yi Chen, Nutley, NJ (US);

Assignee:

PMV Pharmaceuticals, Inc., Princeton, NJ (US);

Attorney:

Wilson Sonsini Goodrich & Rosati

Primary Examiner:

Laura L Stockton

Int. Cl.
CPC ...
C07D 487/10 (2006.01); C07C 237/40 (2006.01); C07D 213/36 (2006.01); C07D 213/38 (2006.01); C07D 213/73 (2006.01); C07D 213/81 (2006.01); C07D 215/12 (2006.01); C07D 231/56 (2006.01); C07D 239/42 (2006.01); C07D 401/04 (2006.01); C07D 401/12 (2006.01); C07D 405/12 (2006.01); C07D 413/12 (2006.01); C07D 417/12 (2006.01); C07D 487/08 (2006.01); C07D 491/107 (2006.01);
U.S. Cl.
CPC ...
C07D 487/10 (2013.01); C07C 237/40 (2013.01); C07D 213/36 (2013.01); C07D 213/38 (2013.01); C07D 213/73 (2013.01); C07D 213/81 (2013.01); C07D 215/12 (2013.01); C07D 231/56 (2013.01); C07D 239/42 (2013.01); C07D 401/04 (2013.01); C07D 401/12 (2013.01); C07D 405/12 (2013.01); C07D 413/12 (2013.01); C07D 417/12 (2013.01); C07D 487/08 (2013.01); C07D 491/107 (2013.01);
Abstract

Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods that restore DNA binding affinity of p53 mutants. The compounds of the present disclosure can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.

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