The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 12, 2024
Filed:
Jun. 19, 2019
Oslo Universitetssykehus Hf, Oslo, NO;
Forschungsverbund Berlin E.v., Berlin, DE;
University of Oulu, Oulu, FI;
Stefan Krauss, Eidsvoll Verk, NO;
Marc Nazare, Berlin, DE;
Lari Lehtio, Oulu, FI;
Jo Waaler, Oslo, NO;
Anita Wegert, Aldenhoven, DE;
Ruben Gerardus George Leenders, Nijmegen, NL;
OSLO UNIVERSITETSSYKEHUS HF, Oslo, NO;
FORSCHUNGSVERBUND BERLIN E.V., Berlin, DE;
UNIVERSITY OF OULU, Oulu, FI;
Abstract
The present invention relates to compounds of formula (I), tautomers, stereoisomers, pharmaceutically acceptable salts and pro-drugs thereof, to processes for their preparation, to pharmaceutical compositions containing such compounds and to their use in therapy wherein a dashed line indicates an optional bond; X represents: a 5- or 6-membered, unsaturated heterocyclic group optionally substituted by one or more (e.g. 1, 2 or 3) substituents independently selected from halogen (i.e. F, Cl, Br, I), Calkyl (e.g. Calkyl), Chaloalkyl (e.g. Chaloalkyl), Calkoxy (e.g. Calkoxy), —CN, —NO, —N(R)2, and —SOR (where each R is independently H or Calkyl, e.g. H or Calkyl); a Ccycloalkyl group optionally substituted by one or more (e.g. 1 or 2) substituents independently selected from Calkyl (preferably Calkyl), Chaloalkyl (e.g. Chaloalkyl), and Calkoxy (e.g. Calkoxy); or an aryl group optionally substituted by one or more (e.g. 1, 2 or 3) substituents independently selected from halogen (i.e. F, Cl, Br, I), Calkyl (e.g Calkyl), Chaloalkyl (e.g. Chaloalkyl), and Calkoxy (e.g. Calkoxy); Y represents: an aryl or heteroaryl group optionally substituted by one or more (e.g. 1, 2 or 3) substituents independently selected from halogen (i.e. F, Cl, Br, I), Calkyl (e.g Calkyl), Chaloalkyl (e.g. Chaloalkyl), and Calkoxy (e.g. Calkoxy); a 5- or 6-membered, saturated heterocyclic group optionally substituted by one or more (e.g. 1, 2 or 3) substituents independently selected from Calkyl (preferably Calkyl), Chaloalkyl (e.g. Chaloalkyl), and Calkoxy (e.g. Calkoxy); or a Ccycloalkyl group optionally substituted by one or more (e.g. 1 or 2) substituents independently selected from Calkyl (preferably Calkyl), Chaloalkyl (e.g. Chaloalkyl), and Calkoxy (e.g. Calkoxy); and Z represents: an aryl group optionally substituted by one or more (e.g. 1, 2 or 3) substituents independently selected from halogen (i.e. F, Cl, Br, I), Calkyl (e.g. Calkyl), Chaloalkyl (e.g. Chaloalkyl), Calkoxy (e.g. Calkoxy), —CN, —NO, —N(R), and —SOR (where each R is independently H or Calkyl, e.g. H or Calkyl); or an unsaturated, 5- to 10-membered mono- or bicyclic heterocyclic group optionally substituted by one or more (e.g. 1, 2 or 3) substituents independently selected from halogen (i.e. F, Cl, Br, I), Calkyl (e.g. Calkyl), Chaloalkyl (e.g. Chaloalkyl), Calkoxy (e.g. Calkoxy), —CN, —NO, —N(R), and —SOR (where each R is independently H or Calkyl, e.g. H or Calkyl). These compounds find particular use in the treatment and/or prevention of a disease or disorder responsive to inhibition of tankyrase 1 and/or 2, for example a disorder which is mediated by tankyrase 1 and/or 2 such as cancer.