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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11925708 B1

PDFFull Text
Date of Patent:
Mar. 12, 2024

Filed:

Oct. 24, 2022

Method for making modified polyvinyl alcohol embolic microsphere

Applicant:

Jiangnan University, Wuxi, CN;

Inventors:

Liping Zhang, Wuxi, CN;

Yi Zhu, Wuxi, CN;

Wenlong Wang, Wuxi, CN;

Caihua Ni, Wuxi, CN;

Assignee:

JIANGNAN UNIVERSITY, Wuxi, CN;

Attorney:

HAUPTMAN HAM, LLP

Primary Examiner:

Tracy Liu

Assistant Examiner:

Abdulrahman Abbas

Int. Cl.
CPC ...
C08F 116/06 (2006.01); A61K 9/00 (2006.01); A61K 9/16 (2006.01); A61K 31/585 (2006.01); A61K 45/06 (2006.01); A61K 47/32 (2006.01); A61K 49/04 (2006.01); A61L 24/00 (2006.01); A61L 24/04 (2006.01); A61L 24/06 (2006.01); A61L 24/10 (2006.01); B82Y 5/00 (2011.01); C08F 2/48 (2006.01); C08F 8/14 (2006.01); C08F 8/36 (2006.01); C08F 220/58 (2006.01); C08F 222/38 (2006.01); C08F 226/10 (2006.01); C08F 261/04 (2006.01); C08L 59/04 (2006.01);
U.S. Cl.
CPC ...
A61K 9/1682 (2013.01); A61K 9/1635 (2013.01);
Abstract

The invention provides a making method of modified polyvinyl alcohol embolic microspheres. First, polyvinyl alcohol dimethyl sulfoxide solution is added to acryloyl chloride dichloromethane solution for reaction, then taurine solution is added to the above solution for further reaction, so that functional groups are introduced into the side chains of polyvinyl alcohol, then blank microspheres are prepared by suspension crosslinking method, and finally, drug-loaded modified polyvinyl alcohol embolic microspheres are prepared. The invention aims at improving the drug loading rate and drug loading speed of the microspheres. Through modification, the crystallinity of polyvinyl alcohol is weakened, the swelling in water is accelerated, and the application effect of the microspheres is improved.

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