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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11925690 B1

PDFFull Text
Date of Patent:
Mar. 12, 2024

Filed:

Jun. 13, 2019

Bifunctional molecules for targeting rpn11

Applicant:

Amphista Therapeutics Ltd, England, GB;

Inventors:

Alessio Ciulli, Dundee, GB;

Andrea Testa, Dundee, GB;

Scott Hughes, Dundee, GB;

Steven Peter Butcher, Dundee, GB;

Assignee:

AMPHISTA THERAPEUTICS LIMITED, London, GB;

Attorneys:

Casimir Jones SC

Lisa Mueller

Primary Examiner:

Nizal S Chandrakumar

Int. Cl.
CPC ...
A61K 47/60 (2017.01); A61K 31/277 (2006.01); A61K 31/351 (2006.01); A61K 31/404 (2006.01); A61K 31/407 (2006.01); A61K 31/4184 (2006.01); A61K 31/423 (2006.01); A61K 31/428 (2006.01); A61K 31/4375 (2006.01); A61K 31/44 (2006.01); A61K 31/47 (2006.01); A61K 31/4709 (2006.01); A61K 31/496 (2006.01); A61K 31/506 (2006.01); A61K 31/519 (2006.01); A61K 31/5355 (2006.01); A61K 31/551 (2006.01); A61K 47/55 (2017.01); C07D 417/14 (2006.01); C07D 495/14 (2006.01);
U.S. Cl.
CPC ...
A61K 47/60 (2017.08); A61K 31/277 (2013.01); A61K 31/351 (2013.01); A61K 31/404 (2013.01); A61K 31/407 (2013.01); A61K 31/4184 (2013.01); A61K 31/423 (2013.01); A61K 31/428 (2013.01); A61K 31/4375 (2013.01); A61K 31/44 (2013.01); A61K 31/47 (2013.01); A61K 31/4709 (2013.01); A61K 31/496 (2013.01); A61K 31/506 (2013.01); A61K 31/519 (2013.01); A61K 31/5355 (2013.01); A61K 31/551 (2013.01); A61K 47/55 (2017.08); C07D 417/14 (2013.01); C07D 495/14 (2013.01);
Abstract

The invention provides for bifunctional molecules comprising an Rpn11 binding partner and a target protein binding partner. A bifunctional molecule according to the invention binds to Rpn11 and to the target protein, thereby facilitating degradation of the target protein bound to the target protein binding partner. The invention also provides for use of a bifunctional molecule for preventing or treating disease.

Find Patent Forward Citations

Ciulli, Alessio. (2024). Bifunctional molecules for targeting rpn11 (U.S. Patent No. 11925690). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11925690

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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