The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 12, 2024
Filed:
May. 23, 2019
Applicants:
Mor Research Applications Ltd., Tel Aviv, IL;
Bar Ilan University, Ramat Gan, IL;
Inventors:
Edith Hochhauser, Ramat Gan, IL;
Arie-Lev Gruzman, Tzur Hadassah, IL;
Elena Trifonov, Petah-Tiqwa, IL;
Assignees:
MOR RESEARCH APPLICATIONS LTD., Ramat Gan, IL;
BAR-ILAN UNIVERSITY, Ramat Gan, IL;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/513 (2006.01); A61K 38/06 (2006.01); A61K 38/07 (2006.01); A61P 9/10 (2006.01); C07D 239/47 (2006.01); C07K 5/083 (2006.01); C07K 5/087 (2006.01); C07K 5/103 (2006.01); C07K 5/107 (2006.01); C07K 5/113 (2006.01);
U.S. Cl.
CPC ...
A61K 31/513 (2013.01); A61K 38/06 (2013.01); A61K 38/07 (2013.01); A61P 9/10 (2018.01); C07D 239/47 (2013.01); C07K 5/0808 (2013.01); C07K 5/0812 (2013.01); C07K 5/1008 (2013.01); C07K 5/101 (2013.01); C07K 5/1016 (2013.01); C07K 5/1021 (2013.01);
Abstract
Peptides, peptidomimetics and small molecules, collectively referred to as 'decoy peptides', are provided, which interfere with binding to a TIR domain of a toll-like receptor 4 (TLR4), and inhibit a TLR4-induced signaling pathway. These decoy peptides may be useful for treating diseases associated with induction of TLR4 signaling pathway such as a disease or disorder secondary to a cardiovascular disease, sepsis or an inflammatory disease.