The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 12, 2024
Filed:
Mar. 29, 2021
Applicant:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., Jerusalem, IL;
Inventors:
Yinon Ben-Neriah, Mevasseret Zion, IL;
Guy Brachya, Jerusalem, IL;
Ido Burstain, Moshav Sde-Yaakov, IL;
Waleed Minzel, Kafr-Kanna, IL;
Irit Snir-Alkalay, Mevasseret Zion, IL;
Joseph P. Vacca, Telford, PA (US);
Dansu Li, Warrington, PA (US);
Assignee:
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/506 (2006.01); A61P 35/02 (2006.01); C07D 403/04 (2006.01); C07D 405/14 (2006.01); C07D 413/14 (2006.01);
U.S. Cl.
CPC ...
A61K 31/506 (2013.01); A61P 35/02 (2018.01); C07D 403/04 (2013.01); C07D 405/14 (2013.01); C07D 413/14 (2013.01);
Abstract
The present invention provides pyrazole pyrimidine derivatives which inhibit Casein kinase I (CKI) and/or Interleukin-1 receptor-associated kinase 1 (IRAKI) and methods of their manufacture, compositions comprising them and uses thereof in methods of treating malignant disease and disorders and methods for treating inflammatory diseases and disorders.