The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 05, 2024

Filed:

Aug. 16, 2019
Applicants:

Northeastern University, Boston, MA (US);

The General Hospital Corporation, Boston, MA (US);

Inventors:

Tania Konry, Boston, MA (US);

Martin L. Yarmush, Newton, MA (US);

Assignees:

Northeastern University, Boston, MA (US);

The General Hospital Corporation, Boston, MA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
B01L 3/00 (2006.01); B01F 25/433 (2022.01); B01F 33/30 (2022.01); G01N 21/64 (2006.01); G01N 33/53 (2006.01); G01N 33/543 (2006.01);
U.S. Cl.
CPC ...
G01N 33/54313 (2013.01); B01F 25/4331 (2022.01); B01F 33/30 (2022.01); B01L 3/5027 (2013.01); B01L 3/502715 (2013.01); B01L 3/502761 (2013.01); B01L 3/502776 (2013.01); G01N 21/6428 (2013.01); G01N 33/5304 (2013.01); G01N 33/54366 (2013.01); B01L 2200/0605 (2013.01); B01L 2200/0647 (2013.01); B01L 2300/0654 (2013.01); B01L 2300/0816 (2013.01); B01L 2300/0867 (2013.01); B01L 2300/087 (2013.01); B01L 2300/0883 (2013.01); B01L 2400/0487 (2013.01); G01N 2021/6439 (2013.01); G01N 2201/061 (2013.01);
Abstract

Microfluidic devices for use with reagents bound to microspheres for determination of the concentration of an analyte in a liquid sample are provided. The devices include two sequential mixing channels that promote rapid binding of microsphere-bound reagents with reagents in solution and a means for detecting labeled microsphere-bound reaction products. Also provided are methods for using the devices with microsphere-bound reagents to determine the concentration of an analyte in a liquid sample and to measure the binding affinity of antibody for an antigen.


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