The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 05, 2024
Filed:
Oct. 03, 2017
Compositions, devices and methods for the control in vitro of chemical microambient in cell cultures
Alma Mater Studiorum—università Di Bologna, Bologna, IT;
Stefania Rapino, Bologna, IT;
Francesco Zerbetto, Bologna, IT;
Gastone Castellani, Bologna, IT;
Stefano Salvioli, Bologna, IT;
Beatrice Fraboni, Bologna, IT;
Isabella Zironi, Caselecchio di Reno, IT;
Maria Conte, Marzabotto, IT;
Claudio Franceschi, Bologna, IT;
Daniela Salvatore, Lanciano, IT;
Maila Becconi, Nuoro, IT;
Alma Mater Studiorum—Università di Bologna, Bologna, IT;
Abstract
The present invention relates to compositions comprising a polymeric matrix or a gel containing functional enzymes capable of re-creating under culture conditions the cell microenvironment existing in vivo. The present invention also relates to devices for cell cultures comprising such compositions, in particular hydrogel and the use thereof to control the chemical microenvironment of a cell culture or mimic physiological or pathological conditions of the in vivo cells. The compositions and the devices described herein could be also used in vitro for evaluating the therapeutic effect of a compound on a determined cell line or on primary cells.