The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 05, 2024
Filed:
Apr. 11, 2023
Shandong Focusfreda Biotech Co., Ltd, Shandong, CN;
Jinmao You, Shandong, CN;
Lei Liu, Shandong, CN;
Chuanli Kang, Shandong, CN;
Shuiqiang Yu, Shandong, CN;
Deqiang Zheng, Shandong, CN;
Qing Li, Shandong, CN;
Shuai Du, Shandong, CN;
Xinxin Shi, Shandong, CN;
Qiang Liu, Shandong, CN;
Liwei Tang, Shandong, CN;
Shaojie Lian, Shandong, CN;
Meixia Zhang, Shandong, CN;
SHANDONG FOCUSFREDA BIOTECH CO., LTD, Shandong, CN;
Abstract
The present invention relates to a preparation and purification method for cationic quaternary ammonium salt of sodium hyaluronate in homogeneous medium. By adding a homogeneous solvent and a sodium hyaluronate solid to a vessel, heating the vessel until the contents are dissolved to form a homogeneous system, adding an aqueous solution of 2,3-epoxypropyltrimethylammonium chloride (GTA) to the homogeneous system, then adding a base catalyst, and stirring at a preset temperature to carry out a graft reaction, a graft product is obtained wherein 2,3-epoxypropyltrimethylammonium chloride is grafted to the oxygen atom of the hydroxymethyl group of sodium hyaluronate. By using the method, a graft product wherein 2,3-epoxypropyltrimethylammonium chloride is grafted to the oxygen atom of the hydroxymethyl group of sodium hyaluronate is obtained. Addition of salts is avoided during the reaction, a grafting yield up to 0.69 is obtained, and coagulation occurred to the product is effectively solved.