The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 05, 2024
Filed:
Aug. 19, 2021
Xencor, Inc., Monrovia, CA (US);
John R. Desjarlais, Pasadena, CA (US);
Gregory Moore, Azusa, CA (US);
Michael Hedvat, Encino, CA (US);
Juan Diaz, Anaheim Hills, CA (US);
Veronica Gusti Zeng, Duarte, CA (US);
Xencor, Inc., Pasadena, CA (US);
Abstract
Provided herein are novel anti-CD28×anti-B7H3 (also referred to as 'αCD28×αB7H3') heterodimeric bispecific antibodies and methods of using such antibodies for the treatment of cancers. Subject αCD28×αB7H3 antibodies are capable of agonistically binding to CD28 costimulatory molecules on T cells and targeting to B7H3 on tumor cells. Thus, such antibodies selectively enhance anti-tumor activity at tumor sites while minimizing peripheral toxicity. The subject antibodies provided herein are particularly useful for enhancing anti-tumor activity when used in combination with other anti-cancer therapies.