The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 05, 2024

Filed:

Mar. 18, 2021
Applicant:

Genentech, Inc., South San Francisco, CA (US);

Inventors:

Wei-Ching Liang, South San Francisco, CA (US);

Joseph R. Arron, South San Francisco, CA (US);

Daryle Depianto, South San Francisco, CA (US);

Wendy Green Halpern, South San Francisco, CA (US);

WeiYu Lin, South San Francisco, CA (US);

Patrick J. Lupardus, South San Francisco, CA (US);

Thirumalai Rajan Ramalingam, South San Francisco, CA (US);

Dhaya Seshasayee, South San Francisco, CA (US);

Tianhe Sun, South San Francisco, CA (US);

Tulika Tyagi, South San Francisco, CA (US);

Jia Wu, South San Francisco, CA (US);

Yan Wu, South San Francisco, CA (US);

Jian Ping Yin, South San Francisco, CA (US);

Assignee:

GENENTECH, INC., South San Francisco, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/22 (2006.01); A61K 39/00 (2006.01); A61K 39/395 (2006.01); A61P 11/00 (2006.01); C07K 16/46 (2006.01);
U.S. Cl.
CPC ...
C07K 16/22 (2013.01); A61P 11/00 (2018.01); C07K 16/464 (2013.01); A61K 39/39533 (2013.01); A61K 39/39566 (2013.01); A61K 2039/505 (2013.01); C07K 2317/24 (2013.01); C07K 2317/31 (2013.01); C07K 2317/41 (2013.01); C07K 2317/565 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01);
Abstract

The invention provides isoform-selective anti-TGFβ antibodies and methods of using the same. In particular, isoform-selective anti-TGFβ2, anti-TGFβ3, and anti-TGFβ2/3 monoclonal antibodies are provided, e.g., for the treatment of fibrosis and other TGFβ-related disorders.


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