The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 05, 2024
Filed:
Jun. 27, 2023
Agios Pharmaceuticals, Inc., Cambridge, MA (US);
Lucrezia De Pascalis, Cambridge, MA (US);
Heather Jane Finlay, Skillman, NJ (US);
Sandra King, Jamaica Plain, MA (US);
Zenon D. Konteatis, Chatham Township, NJ (US);
Brian C. Shook, Holliston, MA (US);
Agios Pharmaceuticals, Inc., Cambridge, MA (US);
Abstract
The disclosure relates to compounds of Formula I or a pharmaceutically acceptable salt thereof, wherein, m, R-R, R, and L are defined herein. These compounds are useful in methods for stabilizing a mutant PAH protein or reducing blood phenylalanine concentration in a subject suffering from phenylketonuria. In some embodiments, the mutant PAH protein contains at least one R408W, R261Q, R243Q, Y414C, L48S, A403V, I65T, R241C, L348V, R408Q, or V388M mutation. In other embodiments, the mutant PAH protein contains at least one R408W, Y414C, I65T, F39L, R408Q, L348V, R261Q, A300S, or L48S mutation.