The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 05, 2024

Filed:

Mar. 23, 2021
Applicant:

Rigel Pharmaceuticals, Inc., South San Francisco, CA (US);

Inventors:

Vanessa Taylor, San Francisco, CA (US);

Jiaxin Yu, Foster City, CA (US);

Esteban Masuda, Menlo Park, CA (US);

Ihab Darwish, San Carlos, CA (US);

Yan Chen, Foster City, CA (US);

Assignee:

;Eli Lilly and Company, Indianapolis, IN (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 413/12 (2006.01); A61K 31/553 (2006.01); A61P 29/00 (2006.01); A61P 37/02 (2006.01); C07D 413/14 (2006.01); C07D 471/10 (2006.01); C07D 487/08 (2006.01); C07D 491/107 (2006.01);
U.S. Cl.
CPC ...
C07D 413/14 (2013.01); C07D 471/10 (2013.01); C07D 487/08 (2013.01); C07D 491/107 (2013.01);
Abstract

Disclosed herein are kinase inhibitory compounds, such as a receptor-interacting protein-1 (RIP1) kinase inhibitor compounds, as well as pharmaceutical compositions and combinations comprising such inhibitory compounds. The disclosed compounds, pharmaceutical compositions, and/or combinations may be used to inhibit a RIP1 kinase in vivo or ex vivo, and also may treat or prevent a kinase-associated disease or condition, particularly a RIP1-associated disease or condition.


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