The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 05, 2024
Filed:
Apr. 23, 2021
Applicant:
Valo Health, Inc., Boston, MA (US);
Inventors:
Kenneth W. Bair, Wellesley, MA (US);
Nicholas Barczak, Waterford, CT (US);
Bingsong Han, Westwood, MA (US);
David R. Lancia, Jr., Boston, MA (US);
Cuixian Liu, Madison, CT (US);
Matthew W. Martin, Arlington, MA (US);
Pui Yee Ng, Lexington, MA (US);
Aleksandra Rudnitskaya, Roslindale, MA (US);
Jennifer R. Thomason, Clinton, MA (US);
Mary-Margaret Zablocki, Revere, MA (US);
Xiaozhang Zheng, Lexington, MA (US);
Assignee:
VALO HEALTH, INC., Boston, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C07C 259/06 (2006.01); A61K 31/185 (2006.01); A61K 31/277 (2006.01); A61K 31/397 (2006.01); A61K 31/4035 (2006.01); A61K 31/407 (2006.01); A61K 31/417 (2006.01); A61K 31/4184 (2006.01); A61K 31/435 (2006.01); A61K 31/438 (2006.01); A61K 31/44 (2006.01); A61K 31/4439 (2006.01); A61K 31/451 (2006.01); A61K 31/495 (2006.01); A61K 31/5377 (2006.01); C07D 207/10 (2006.01); C07D 207/267 (2006.01); C07D 209/08 (2006.01); C07D 209/42 (2006.01); C07D 209/44 (2006.01); C07D 209/46 (2006.01); C07D 211/16 (2006.01); C07D 211/58 (2006.01); C07D 213/56 (2006.01); C07D 213/65 (2006.01); C07D 213/75 (2006.01); C07D 213/81 (2006.01); C07D 215/12 (2006.01); C07D 221/20 (2006.01); C07D 231/14 (2006.01); C07D 231/18 (2006.01); C07D 233/36 (2006.01); C07D 233/38 (2006.01); C07D 233/68 (2006.01); C07D 235/14 (2006.01); C07D 235/30 (2006.01); C07D 239/20 (2006.01); C07D 239/22 (2006.01); C07D 241/08 (2006.01); C07D 241/12 (2006.01); C07D 249/18 (2006.01); C07D 257/04 (2006.01); C07D 261/18 (2006.01); C07D 277/56 (2006.01); C07D 295/155 (2006.01); C07D 295/192 (2006.01); C07D 307/68 (2006.01); C07D 317/68 (2006.01); C07D 333/70 (2006.01); C07D 401/04 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 405/12 (2006.01); C07D 409/04 (2006.01); C07D 409/12 (2006.01); C07D 417/04 (2006.01); C07D 417/12 (2006.01); C07D 471/04 (2006.01); C07D 471/10 (2006.01); C07D 487/04 (2006.01); C07D 487/08 (2006.01); C07D 487/10 (2006.01); C07D 491/10 (2006.01); C07D 493/08 (2006.01); C07D 495/10 (2006.01); C07D 498/04 (2006.01); C07D 513/10 (2006.01);
U.S. Cl.
CPC ...
C07C 259/06 (2013.01); A61K 31/185 (2013.01); A61K 31/277 (2013.01); A61K 31/397 (2013.01); A61K 31/4035 (2013.01); A61K 31/407 (2013.01); A61K 31/417 (2013.01); A61K 31/4184 (2013.01); A61K 31/435 (2013.01); A61K 31/438 (2013.01); A61K 31/44 (2013.01); A61K 31/4439 (2013.01); A61K 31/451 (2013.01); A61K 31/495 (2013.01); A61K 31/5377 (2013.01); C07D 207/10 (2013.01); C07D 207/267 (2013.01); C07D 209/08 (2013.01); C07D 209/42 (2013.01); C07D 209/44 (2013.01); C07D 209/46 (2013.01); C07D 211/16 (2013.01); C07D 211/58 (2013.01); C07D 213/56 (2013.01); C07D 213/65 (2013.01); C07D 213/75 (2013.01); C07D 213/81 (2013.01); C07D 215/12 (2013.01); C07D 221/20 (2013.01); C07D 231/14 (2013.01); C07D 231/18 (2013.01); C07D 233/36 (2013.01); C07D 233/38 (2013.01); C07D 233/68 (2013.01); C07D 235/14 (2013.01); C07D 235/30 (2013.01); C07D 239/20 (2013.01); C07D 239/22 (2013.01); C07D 241/08 (2013.01); C07D 241/12 (2013.01); C07D 249/18 (2013.01); C07D 257/04 (2013.01); C07D 261/18 (2013.01); C07D 277/56 (2013.01); C07D 295/155 (2013.01); C07D 295/192 (2013.01); C07D 307/68 (2013.01); C07D 317/68 (2013.01); C07D 333/70 (2013.01); C07D 401/04 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 405/12 (2013.01); C07D 409/04 (2013.01); C07D 409/12 (2013.01); C07D 417/04 (2013.01); C07D 417/12 (2013.01); C07D 471/04 (2013.01); C07D 471/10 (2013.01); C07D 487/04 (2013.01); C07D 487/08 (2013.01); C07D 487/10 (2013.01); C07D 491/10 (2013.01); C07D 493/08 (2013.01); C07D 495/10 (2013.01); C07D 498/04 (2013.01); C07D 513/10 (2013.01); Y02A 50/30 (2018.01);
Abstract
The present invention relates to inhibitors of histone deacetylases, in particular HDAC8, that are useful for the treatment of cancer and other diseases and disorders, as well as the synthesis and applications of said inhibitors.