The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 05, 2024
Filed:
Mar. 08, 2023
Applicant:
Krystal Biotech, Inc., Pittsburgh, PA (US);
Inventors:
Suma Krishnan, Pittsburgh, PA (US);
Trevor Parry, San Diego, CA (US);
Dana Michelle Previte, Sewickley, PA (US);
Mary Jane Duermeyer, Glenshaw, PA (US);
Assignee:
Krystal Biotech, Inc., Pittsburgh, PA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/869 (2006.01); A61K 35/763 (2015.01); A61K 38/19 (2006.01); A61K 38/20 (2006.01); A61K 48/00 (2006.01); A61P 35/00 (2006.01); C12N 7/00 (2006.01); C12N 15/24 (2006.01); C12N 15/26 (2006.01); C12N 15/86 (2006.01);
U.S. Cl.
CPC ...
A61K 48/0066 (2013.01); A61K 38/193 (2013.01); A61K 38/2013 (2013.01); A61K 38/208 (2013.01); A61P 35/00 (2018.01); C12N 7/00 (2013.01); C12N 15/86 (2013.01); C12N 2710/16622 (2013.01); C12N 2710/16633 (2013.01); C12N 2710/16643 (2013.01); C12N 2710/16662 (2013.01); C12N 2710/16671 (2013.01);
Abstract
The present disclosure provides recombinant nucleic acids comprising one or more polynucleotides encoding an immunomodulatory polypeptide (e.g., a pro-inflammatory cytokine such as a human IL-2 or IL-12 polypeptide); viruses comprising the recombinant nucleic acids; compositions and formulations comprising the recombinant nucleic acids and/or viruses; methods of their use (e.g., for the treatment of cancer, such as lung cancer); and articles of manufacture or kits thereof.